For Jamie Shirey, FNP-BC, her journey into midlife wellness started with frustration, first as a clinician, then as a patient.

Early in her career as a nurse practitioner in traditional healthcare, she saw the same story repeat especially in women in their 40s and 50s. Fatigue, brain fog, low libido, weight gain, anxiety. Too often, they were told it was “just aging” or handed a prescription without real answers.

Then Jamie started experiencing those same symptoms herself. She was eating well, exercising, and doing all the “right” things but still felt off. The fatigue, mental fog, and disconnection were real, and the response she got from her own providers mirrored what she’d seen in her patients: dismissal.

That was the turning point.

Jamie began diving deep into functional medicine, hormone optimization, metabolic health, inflammation, and insulin resistance. She learned how to address the real root causes of midlife health struggles first healing herself, and then transforming her approach with patients.

Today, Jamie is the founder of Midlifesy, a practice devoted to helping women (and men) optimize their hormones, reset their metabolism, and reclaim their energy and confidence. Her passion comes from lived experience and her commitment is to ensure no patient ever feels unseen or unheard during midlife.

Meet the Founder of Midlifesy

Name: Jamie Shirey, FNP-BC
Business: Midlifesy
Location: Pennsylvania
Business Philosophy: Helping midlife women and men restore balance, energy, and confidence through personalized care that goes beyond traditional healthcare
Website: midlifesy.com

“I believe no woman should be told to just ‘eat less and move more’ when what she really needs is to be understood, supported, and empowered.”

What Makes Midlifesy Different?

• Root-cause approach to hormones, metabolism, and energy
• Advanced biomarker testing, continuous glucose monitoring (CGM), wearable tech, and targeted therapies like peptide and hormone optimization to truly personalize each patient’s care. 
• Precision, data-informed care plans tailored to each patient
• Focus on education, empowerment, and lasting lifestyle shifts
• Real-world experience from a provider who’s been in your shoes

A Practice Born from Experience

Jamie’s “aha” moment came in a single sentence she heard as a patient: “It’s simple eat less and move more.”

She walked out of that appointment feeling dismissed but also determined. Even before completing her nurse practitioner program, she knew she would never say those words to a patient. Instead, she made it her mission to learn the deeper science behind midlife health and to find a better way.

Today, her care combines hormone and metabolic optimization, targeted supplementation, lifestyle strategies, and patient education always backed by data, not guesswork.

Tools That Transform Care

At Midlifesy, Jamie uses wearable devices and lab testing to track progress in real time measuring things like HRV (heart rate variability), sleep quality, and recovery. These insights help pinpoint whether issues like cortisol imbalance, inflammation, or hormonal shifts are in play, allowing for tailored interventions that get better, faster results.

“Patients can see their progress in real numbers, not just how they feel and that kind of feedback creates buy-in and momentum.”

Her Mission in Motion

Jamie’s work is about more than symptom relief; it’s about giving midlife women and men the tools, knowledge, and confidence to thrive.

Advice for Fellow Clinicians

“ I don’t just treat symptoms, I see the full picture.”

A Glimpse Into Jamie’s World

• Morning Routine: Protein breakfast, morning sunlight, chai tea latte with almond milk, supplements (yes… all 14 of them), creatine, and most recently colostrum
• Wellness Must-Have: Biohacking with data to prove it
• Creative Escape: Agility training with her Papillon, Mia; photography; hands-on creative projects; travel with her husband; time with her five grown kids and two granddaughters
• Guilty Pleasure: A light-pink cosmo when she’s out and about
• Soundtrack of Her Life: Unstoppable by Sia though some days it’s She Works Hard for the Money or Crazy Train
• Real Talk: “People would be surprised to learn that I once believed the same outdated health advice I now spend my days debunking.”

Looking Ahead

Jamie’s mission is clear to change the conversation around midlife health and to ensure that precision, personalized care becomes the standard, not the exception.

“I’m in a season where I’m finally building what I was meant to build and I’m not slowing down anytime soon.”

Want to Learn More About Jamie Shirey and Midlifesy?
🌐 midlifesy.com
📱@jamie_shireynp